北京大学生物医学前沿创新中心研究员，北京未来基因诊断高精尖创新中心研究员，2008 年本科毕业于武汉大学，2014年毕业于中国科学院北京基因组研究所，获基因组学博士学位。2015 年至2021年在加州大学圣地亚哥分校 Ludwig Cancer Institute 进行博士后研究工作。曾获得 2014 年赛诺菲巴斯德与北京生命科学研究院生物医学奖和中国科学院院长优秀奖等。科研成果发表在 Cancer Cell，Nature Methods 等国际期刊。李国强博士于2021年3月入职北京大学，任北京大学生物医学前沿创新中心和北京未来基因诊断高精尖创新中心研究员。

　　李国强博士一直致力于癌症和表观基因组学交叉领域的机制研究和技术研发，并取得了一系列研究成果：阐明了E3泛素连接酶接头蛋白SPOP促进肾癌发展的致病机制；首次发现了人类体外受精胚胎中异常的DNA甲基化重编程并开发了全新的胚胎植入前表观遗传检测技术；研发了单细胞水平同时捕获染色体构象和 DNA 甲基化的单细胞多组学技术。加入北京大学后，李国强博士课题组将致力于利用单细胞多组学和功能基因组学等研究手段，探索真核细胞内表观遗传修饰，三维基因组构象，以及非编码调控元件在基因表达调控方面的分子机制和功能，并以此为核心对细胞分化、胚胎发育以及重大疾病中基因表达失调的分子机制和可能的治疗手段进行深入研究。

代表性论文

1. Hao Tian, Pengfei Luan, Yaping Liu, Guoqiang Li* “Tet-mediated DNA methylation dynamics affect chromosome organization” Nucleic Acids Research, 52(2024): 3654-3666

2. Guoqiang Li*, Yaping Liu*, Yanxiao Zhang, Naoki Kubo, Miao Yu, Rongxin Fang, Manolis Kellis and Bing Ren. “Joint profiling of DNA methylation and chromatin architecture in single cells.” Nature Methods, 16 (2019): 991–993.
3. Xiaocui Xu*, Guoqiang Li*, Congru Li*, Jing Zhang*, Qiang Wang*, David K Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi YuQian-fei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong E Zhang, Mark Q Martindale and Jiang Liu. “Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.” National Science Review, nwz064 (2019)
4. Congru Li*, Yang Yu*, Yong Fan*, Guoqiang Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “DNA methylation reprogramming of functional elements during mammalian embryonic development.” Cell Discovery 4, no. 28 (2018).
5. Guoqiang Li*, Yang Yu*, Yong Fan*, Congru Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “Genome-wide abnormal DNA methylome of human blastocyst in assisted reproductive technology.” Journal of Genetics and Genomics 44 (2017): 475-481.
6. Guoqiang Li*, Weimin Ci*, Subhradip Karmakar*, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu and Kevin P. White. “SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.” Cancer Cell 25, no. 4 (2014): 455-468.