首页 > 科学研究 > 研究团队

乔杰, 研究员

http://www.puh3rmc.org/
T: +86-10-82266886
E: jie.qiao@263.net

北京大学第三医院生殖医学中心,海淀区花园北路49号

个人简介

  乔杰教授 1987 年毕业于北京医科大学医学系,获学士学位,1996 年获得北医大博士学位,2002 年至 2003 年在美国斯坦福大学医学中心从事博士后研究工作,曾于香港大学玛丽医院(Queen Mary Hospital)妇产科做访问学者,并获香港临时注册医师资格。1990 年至今先后担任北京医科大学第三医院妇产科住院医师、主治医师、副主任医师、副教授; 2001 年至今先后担任北京大学第三医院妇产科主任医师、教授、产科主任; 2003 年至今担任生殖医学中心主任,2010 年入选“长江学者特聘教授”;2012 年起担任北大第三医院院长,2017 年当选中国工程院院士。

  乔杰教授现任国家妇产疾病(生殖健康)临床医学研究中心主任,教育部辅助生殖重点实验室主任,973“生殖与发育重大专项”首席科学家,国家自然科学基金创新研究群体“生殖细胞发育”首席专家,Human Reproductive Update (中文版)及《中华生殖与避孕》总编,现任国家妇产疾病临床医学研究中心主任,中国女医师协会会长,中国医师协会生殖医学专业委员会主任委员,中华医学会妇产科学分会委员会副主任委员等。

  乔杰教授领导的研究团队构建了世界首个高精度重组定位女性个人遗传图谱,并绘制出人类生殖细胞和植入前胚胎发育过程转录组及 DNA 甲基化组全景图,系统解析人类配子、胚胎发育调控机制,成功建立了新的植入前胚胎遗传病诊断新方法并实现临床转化。对导致不孕的最常见疾病—多囊卵巢综合征(PCOS)卵成熟障碍、炎症和代谢异常等新机制进行了系统研究,建立代谢异常预测模型,制定出适用于中国 PCOS 的诊断标准。目前已以第一或通讯作者在Lancet 、JAMA 、Cell 、Nature 和Science 等期刊发表 SCI 文章 199 篇。主编《生殖工程学》等专著 19 部,获发明专利等 6 项,获国家科技进步二等奖3 项、省部级一等奖3 项及何梁何利科学与技术进步奖等。

  乔杰实验室在 ICG 的研究方向是与生殖健康相关的临床和基础研究,集中在生殖细胞发育机制和不孕症相关疾病发病机制的研究。

  1. 胚胎发育机制与不孕原因初探:胚胎发育、生殖细胞发生与成熟的分子机制以及异常状态下的病理机制;

  2. 助生殖技术的完善与新技术的探讨及安全性评估(出生后代随访、动物模型);

  3. 建立新的胚胎遗传分析方法,适应于各种单基因疾病及染色体异常;

  4. 常见女性生殖内分泌疾病的发病机制与防治策略的探讨。

  代表性论文

  1. Bian S, Hou Y, Zhou X, Li X, Yong J, Wang Y, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J*, Tang Fuchou*, Fu W*. Single-cell multiomics sequencing and analyses of human colorectal cancer. Science, 362: 1060-1063 (2018). 
  2. Zhong S, Zhang S, Fan X, Wu Q, Yan L, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang Fuchou*, Zhang J*, Qiao J*, Wang X*. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature, 555: 524-528 (2018) .
  3. Wang M, Liu X, Chang G, Chen Y, An G, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F*, Zhao X*, Qiao J*. Single Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis. Cell Stem Cell. 2018; 23(4):599-614.e4.
  4. Gao S, Yan L, Wang R, Li J, Yong J, Zhou X, Wei Y, Wu X, Wang X, Fan X, Yan J, Zhi X, Gao Y, Guo H, Jin X, Wang W, Mao Y, Wang F, Wen L, Fu W, Ge H*, Qiao J*, Tang F*. Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing. Nat Cell Biol. 2018; 20:721-734.
  5. Zhu P, Guo H, Ren Y, Hou Y, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J*, Tang F*.Single-cell DNA methylome sequencing of human preimplantation embryos. Nat Genet. 2018;50(1):12-19.
  6. Wang H, Gao H, Chi H, Zeng L, Xiao W, Wang Y, Li R, Liu P, Wang C, Tian Q, Zhou Z, Yang J, Liu Y, Wei R, Mol BWJ, Hong T*, Qiao J*. Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer. JAMA.2017;318(22):2190-2198.
  7. Li L, Dong J, Yan L, Yong J, Liu X, Hu Y, Fan X, Wu X, Guo H, Wang X, Zhu X, Li R, Yan J, Wei Y, Zhao Y, Wang W, Ren Y, Yuan P, Yan Z, Hu B, Guo F, Wen L, Tang F, Qiao J. Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions. Cell Stem Cell. 2017 Jun 1;20(6):858-873.e4.
  8. Qi X, Zhang B, Zhao Y, Li R, Chang HM, Pang Y, Qiao J. Hyperhomocysteinemia promotes insulin resistance and adipose tissue inflammation in PCOS mice through modulating M2 macrophage polarization via estrogen suppression. Endocrinology. 2017 Mar 15. doi: 10.1210/en.2017-00039.
  9. Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F, Qiao J. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Res. 2017 Feb;27(2):165-183.
  10. Huang Y, Gao JM, Zhang CM, Zhao HC, Zhao Y, Li R, Yu Y, Qiao J. Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults. Reproduction. 2016 Dec;152(6):705-714.
  11. Chang HM, Qiao J, Leung PC. Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors. Hum Reprod Update. 2016 Dec;23(1):1-18.
  12. Ren Y, Zhi X, Zhu X, Huang J, Lian Y, Li R, Jin H, Zhang Y, Zhang W, Nie Y, Wei Y, Liu Z, Song D, Liu P, Qiao J, Yan L. Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy. J Genet Genomics. 2016 Sep 20;43(9):541-7.
  13. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Tracing the expression of circular RNAs in human pre-implantation embryos. Genome Biol. 2016 Jun 17;17(1):130.
  14. Wang TR, Yan J, Lu CL, Xia X, Yin TL, Zhi X, Zhu XH, Ding T, Hu WH, Guo HY, Li R, Yan LY, Qiao J. Human single follicle growth in vitro from cryopreserved ovarian tissue after slow freezing or vitrification. Hum Reprod. 2016 Apr;31(4):763-73.
  15. Yan L, Huang L, Xu L, Huang J, Ma F, Zhu X, Tang Y, Liu M, Lian Y, Liu P, Li R, Lu S, Tang F, Qiao J, Xie XS. Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses. Proc Natl Acad Sci USA. 2015 Dec 29;112(52):15964-9.
  16. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J. The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells. Cell. 2015 Jun 4;161(6):1437-52.
  17. Zhao Y, Zhang C, Huang Y, Yu Y, Li R, Li M, Liu N, Liu P, Qiao J. Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K/AKT/NF-κB signaling in the granulosa cells of PCOS patients. J Clin Endocrinol Metab. 2015 Jan;100(1):201-11.
  18. Qiao J, Li R. Fertility preservation: challenges and opportunities. Lancet. 2014 Oct 4;384(9950):1246-7.
  19. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang F, Qiao J. The DNA methylation landscape of human early embryos. Nature. 2014 Jul 31;511(7511):606-10.
  20. Wang TR, Yan LY, Yan J, Lu CL, Xia X, Yin TL, Zhu XH, Gao JM, Ding T, Hu WH, Guo HY, Li R, Qiao J. Basic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro.Hum Reprod. 2014 Mar;29(3):568-76.
  21. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang F, Xie XS, Qiao J. Genome analyses of single human oocytes. Cell. 2013 Dec 19;155(7):1492-506.