首页 > Research > Faculty

Xuefei Zhang, PI


T:
E: Xuefei_Zhang10@pku.edu.cn

Rm. 403, Integrated Science Research Center No.2,Peking University

Profile

2021-Present, Principal Investigator, Beijing Advanced Innovation Center for Genomics

2021-Present, Principal Investigator, Biomedical Pioneering Innovation Center, Peking University

2020-2021, Instructor, Harvard Medical School/Boston Children’s Hospital, Boston

2016-2020,Postdoctoral Research Fellow, Harvard Medical School/Boston Children’s Hospital, Boston

2010-2016, Ph.D. in Biochemistry and Molecular Biology, Peking University

2006-2010, B.S. in Biotechnology, Huazhong University of Science and Technology

The diversification of antibody is the hallmark of adaptive immunity, which can protect against antigen infection. The antibody diversification is from the RAG-mediated V(D)J recombination, activation-induced cytidine deaminase (AID)-initiated class switch recombination (CSR) and somatic hypermutation (SHM). While the off-targets of RAG- and AID-mediated recombination or mutation severely affect the genome stability and human health. Our group uses the combination of gene editing and genomics to systematically study the mechanism of antibody diversification, and the roles of dynamic chromatin structure in maintaining genomic stability, which also contribute to the understanding of immunological deficiency-related diseases and genome instability-related diseases.

  

  Selected Publications

  1. Zhang X*, Yoon HS, Chapdelaine-Williams AM, Kyritsis N, Alt FW*. Physiological role of the 3’IgH CBEs super anchor in antibody class switching Proc Natl Acad Sci U S A. 2021, 118(3):e2024392118. (* Co-corresponding author) 
  2. Zhang X, Zhang Y, Ba Z, Kyritsis N, Casellas R, Alt FW*. Fundamental roles of chromatin loop extrusion in antibody class switching. Nature. 2019, 575(7782):385-389.
  3. Zhang Y#, Zhang X#, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW*. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 573(7775):600-604. (# Co-first author)
  4. Panchakshari RA#, Zhang X#, Kumar V, Du Z, Wei PC, Kao J, Dong J*, Alt FW*. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation. Proc Natl Acad Sci U S A. 2018, 115(4):762-767. (# Co-first author)