Dr. Guoqiang Li received his B.S. in Biotechnology from Wuhan University in 2008, and Ph.D. in Genomics from Beijing Institute of Genomics, Chinese Academy of Sciences in 2014. He did his postdoctoral research at Ludwig Institute for Cancer Research, UC San Diego from 2015 to 2021. He has been honored with multiple awards, including the Chinese Academy of Sciences President Award and Outstanding Graduate and Sanofi Pasteur and Beijing Institutes of Life Science Biomedical Prize in 2014. His findings have been published in renowned journals including Nature Methods and Cancer cell. In 2021, he joined Peking University as a tenure-track Assistant Professor in Biomedical Pioneering Innovation Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG).

　　Dr. Li has been focusing on the mechanisms and technology development in the interaction of cancer and epigenomics, and achieved multiple accomplishments:demonstrated that E3 ligase adaptor SPOP promotes kidney tumorigenesis by acting as a critical regulatory hub, observed that abnormal DNA methylome often occurred in human embryos in assisted reproductive technology (ART) and then developed a patent to detect the DNA methylome instability before embryo implantation, developed a single-cell multi-omics technology that can jointly profile and delineate the heterogeneity of DNA Methylation and chromatin organization in single cells. Looking forward, his research group will use single-cell multi-omics and functional genomics to examine the mechanisms and functions of epigenetic modifications, 3D genome organization, and non-coding cis-regulatory elements in regulating gene expression, which will be the foundation to further understand gene regulation in cell fate decision, embryo development, and its dysregulation in variety of human diseases.

Selected Papers

1. Hao Tian, Pengfei Luan, Yaping Liu, Guoqiang Li* “Tet-mediated DNA methylation dynamics affect chromosome organization” Nucleic Acids Research, 52(2024): 3654-3666

2. Guoqiang Li*, Yaping Liu*, Yanxiao Zhang, Naoki Kubo, Miao Yu, Rongxin Fang, Manolis Kellis and Bing Ren. “Joint profiling of DNA methylation and chromatin architecture in single cells.” Nature Methods, 16 (2019): 991–993.
3. Xiaocui Xu*, Guoqiang Li*, Congru Li*, Jing Zhang*, Qiang Wang*, David K Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi YuQian-fei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong E Zhang, Mark Q Martindale and Jiang Liu. “Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.” National Science Review, nwz064 (2019)
4. Congru Li*, Yang Yu*, Yong Fan*, Guoqiang Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “DNA methylation reprogramming of functional elements during mammalian embryonic development.” Cell Discovery 4, no. 28 (2018).
5. Guoqiang Li*, Yang Yu*, Yong Fan*, Congru Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “Genome-wide abnormal DNA methylome of human blastocyst in assisted reproductive technology.” Journal of Genetics and Genomics 44 (2017): 475-481.
6. Guoqiang Li*, Weimin Ci*, Subhradip Karmakar*, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu and Kevin P. White. “SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.” Cancer Cell 25, no. 4 (2014): 455-468.