Wulan Deng received her B.S. in Biological Science from Peking University in 2006, and Ph.D. in Molecular and Cell Biology from University of Pennsylvania in 2012. From 2013 to 2019 she did her postdoctoral research at the Janelia Research Campus of Howard Hughes Medical Institute and later at University of California, Berkeley. She was awarded with multiple honors including UPenn President Gutmann Leadership Award, CHOP Distinguished Research Trainee Award, and the ASH Merit Award. She published her findings in top journals such as Cell, PNAS, Science, and Blood. She joined Peking University as a tenure-track Assistant Professor in August 2019.

　　Dr. Deng team use a combination of single molecule fluorescent microscopy and genomic approaches to investigate the spatial and temporal dynamics of transcription regulation events, and integrates information from DNA sequences, epigenetic traits, and chromatin spatial organization, to discover new mechanisms of transcription regulation and chromatin regulation in development and diseases.

Selected Publications

1. Wang Z#, Wang B#, Niu D#, Yin C, Bi Y, Cattoglio C, Loh KM, Lavis LD, Ge H, Deng W*. Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells. Nature Structural & Molecular Biology. 2024 (Accepted).
2. Han X, Xing L, Hong Y, ..., Yan J, Deng W, Shen X*. Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.Cell Stem Cell. 2024 May 2;31(5):694-716.e11.
3. Z. Wang, and W. Deng#, Dynamic transcription regulation at the single-molecule level. Developmental Biology 482, 67–81(2022).
4. W. Deng#, X. Shi, R. Tjian, T. E. E. Lionnet, and R. H. Singer#, CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells. Proceedings of the National Academy of Sciences 112, 11870-11875 (2015).
5. S. C. Knight, L. Xie, W. Deng, B. Guglielmi, L. B. Witkowsky, L. Bosanac, E. T. Zhang, M. E. Beheiry, J.-B. Masson, M. Dahan, and Z. Liu, Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science 350, 823-827 (2015).
6. W. Deng*, J. W. Rupon*, I. Krivega, L. Breda, I. Motta, K. S. Jahn, A. Reik, P. D. Gregory, S. Rivella, A. Dean, and G. A. Blobel, Reactivation of developmentally silenced globin genes by forced chromatin looping, Cell 158, 849-860 (2014).
7. W. Deng, J. Lee, H. Wang, J. Miller, A. Reik, P. D. Gregory, A. Dean, and G. A. Blobel, Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244 (2012).
8. T. Tripic*, W. Deng*, Y. Cheng, Y. Zhang, C. R. Vakoc, G. D. Gregory, R. C. Hardison, G. A. Blobel, SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113, 2191–2201 (2009).