Dr. Dong Xing received his PhD from Peking University and did postdoc at Harvard University. He joined BIOPIC at Peking University as an Assistant Professor in 2019. Dong is interested in developing methods to probe the structure and function of the genome in single cells, including accurate amplification and sequencing of the single-cell whole genome, reconstruction of the three-dimensional genome structure and detection of chromatin accessible regions, positioning of nucleosomes and DNA-protein interactions. By leveraging the power of these cutting-edge technologies, he focuses on the study of basic biological questions, such as genome stability, regulation of gene expression and the role of 3D genome organization.
1. L. Tan, D. Xing, N. Daley, X. S. Xie, Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems. Nat Struct Mol Biol 26, 297-307 (2019).
2. L. Tan, D. Xing, C. H. Chang, H. Li, X. S. Xie, Three-dimensional genome structures of single diploid human cells. Science 361, 924-928 (2018).
3. C. Chen, D. Xing, L. Tan, H. Li, G. Zhou, L. Huang, X. S. Xie, Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI). Science 356, 189-194 (2017).
4. Z. Liu, D. Xing, Q. P. Su, Y. Zhu, J. Zhang, X. Kong, B. Xue, S. Wang, H. Sun, Y. Tao, Y. Sun, Super-resolution imaging and tracking of protein-protein interactions in sub-diffraction cellular space. Nat Commun 5, 4443 (2014).
5. S. Kim, E. Brostromer, D. Xing, J. Jin, S. Chong, H. Ge, S. Wang, C. Gu, L. Yang, Y. Q. Gao, X. D. Su, Y. Sun, X. S. Xie, Probing allostery through DNA. Science 339, 816-819 (2013).