Dr. Dong Xing received his PhD in Biochemistry and Molecular Biology from Peking University in 2012 and completed his postdoc training at Harvard University. He joined Biomedical Pioneering Innovation Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG) at Peking University as an Assistant Professor in 2019. During his postdoc research, Dong pioneered several novel single-cell sequencing technologies including Linear Amplification via Transposon Insertion (LIANTI) and Dip-C. LIANTI took advantage of Tn5 transposition and T7 in vitro transcription for whole-genome linear amplification and achieved unprecedented accuracy and sensitivity in terms of detection of genomic variations in single cells. Dip-C was based on highly efficient single-cell chromosome conformation capture technology, which captured five times as many contacts as before and allowed the first three-dimensional structure of a diploid human genome to be reconstructed.
At Peking University, the Xing lab is interested in developing novel genomic and bioinformatic approaches to probe the structure and function of the eukaryotic genome in single cells. We mainly focus on accurate detection of genomic variations,reconstruction of the three-dimensional genome structure, identification of chromatin accessible regions, positioning of nucleosomes and interactions between proteins and DNA. By leveraging the power of these cutting-edge single-cell technologies, we aim to help uncover the mechanisms behind fundamental biological processes, such as genome instability, regulation of gene expression and the role of three-dimensional genome organization. Ultimately, we hope to advance the understanding of the relationship between genome abnormality and disease and bring potential therapeutic strategies.
Selected Publications