Ying Liu is a Principal Investigator of the Beijing Advanced Innovation Center for Genomics, PKU-THU Center for Life Sciences, and Institute of Molecular Medicine at Peking University. She received her B.S. degree in Biochemistry from Nanjing University in 2006, and her Ph.D. degree in Biochemistry in 2011 from the University of Texas Southwestern Medical Center. As a Helen Hay Whitney Fellow, she obtained her postdoctoral training with Prof. Gary Ruvkun at Harvard. On December 2013, she started her own independent lab at Peking University. Dr. Liu’s honors and awards include the HHMI International Research Scholar, China Young Female Scientist Award, Innovators under 35 China from MIT Technology Review, the Nominata Award, and the Stanford Biochemistry Founders' Award for Doctoral Excellence.
Dr.Liu has a long-lasting interest in stress response and homeostatic regulation. In particular, they focus on the molecular mechanisms that govern cellular and organismal responses to mitochondrial stress (low-energy level) and amino acids deprivation (lownutrient level). In addition, they are currently active exploring the physiological function and regulation of N6-methyldeoxyadenine (DNA 6mA) in stress responses. Failure to appropriately respond to different stresses and maintain homeostasis could result in multiple diseases. Therefore, their studies will have therapeutic potential for the treatment of cancer, metabolic disorders, neurodegeneration or aging.
1. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife , e41792 (2019).
2. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology doi: 10.1038/s41556-018-0238-5 (2018).
3. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signaling to promote tumorigenesis and ageing. Nature , 557, 585-589 (2018).
4. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin Extends C. elegans Lifespan through Lysosomal Pathway. eLife , e31268 (2017).
5. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Research , 11, 1182-1196 (2016).
6. Liu Y, Samuel B, Breen P, and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508 (2014) 406-410.