Wensheng Wei received his Bachelor of Science in Biochemistry from Peking University, Ph.D. in Genetics from Michigan State University, and postdoctoral fellowship at Stanford University School of Medicine. The research team focuses on developing gene editing technologies, novel gene and cell therapies, and high-throughput functional genomics techniques. They aim to investigate the molecular mechanisms of major diseases such as cancer and infections, providing new drug targets and strategies for effective treatments.

Selected Publications

1. Bao Y, Pan Q, Xu P, Liu Z, Zhang Z, Liu Y, Xu Y, Yu Y, Zhou Z*, Wei W*. (2023) Unbiased Interrogation of Functional Lysine Residues in Human Proteome. Molecular Cell 83, 4614-4632 e4616.
2. Yi Z, Zhang X, Tang W, Yu Y, Wei X, Zhang X, and Wei W*. (2023) Strand-Selective Base Editing in Mitochondrial DNA using Programmable Deaminases with Targeted Nickase. Nat Biotechnol 42, 498-509.
3. Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, Wang C, Xiao X, Dong X, Guo L, Lu S, Yang C, Tang C, Yang Y, Yu W, Wang, J, Zhou Y, Huang Q, Yisimayi A, Liu S, Huang WJ, Cao Y, Wang Y, Zhou Z, Peng X, Wang J, Xie X, Wei W*. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell 185, 1728-1744 e1716.
4. Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, Wei W*. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology 40(6): 946-955.
5. Xu P, Liu Z, Liu Y, Ma H, Xu Y, Bao Y, Zhu S, Cao Z, Wu Z, Zhou Z and Wei W*. (2021) Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology 39(11), 1403–1413.
6. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology 37, 1059-1069.
7. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi YH, Gao S, Shi Y, Yan J, Zhang Y, Xie Z*, Wei W* and Gao GF*. (2019) Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B. Cell 177, 1-13.
8. Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, Liu Z, He Y and Wei W*. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nature Biotechnology 36, 1203-1210.
9. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nature Biotechnology 34, 1279-1286.
10. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509, 487-91.