Rm. 205, Integrated Science Research Center No.2,Peking University
Wensheng Wei was born in 1969 at Jiangsu province, China. He received his bachelor degree of Biochemistry from Peking University in 1991, and Ph.D. degree of Genetics from Michigan State University in 1999. He then went to Prof. Stanley Cohen's lab at Stanford University School of Medicine for post-doctoral training, and became a research associate in 2005. Dr. Wei returned to Peking University in 2007 and became a principle investigator at the School of Life Sciences. He is currently jointly appointed as Investigator by Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), and Peking-Tsinghua Center for Life Sciences (CLS).
Dr. Wei has published a number of papers in high-profile journals, including Cell, Nature, Nature Biotechnology, and PNAS, as either first or corresponding author. He has been granted four patents, and is the recipient of the follow-ing awards: China Patent Award, Tan Jiazhen Life Science Award, Scientific Chinese Man of the Year, Zheng Changxue Teaching Award, BAYER Investigator Award, Roche Chinese Young Investigator Award, Peking University Dongbao Fellowship, and the most popular teacher of School of Life Sciences award.
The research of Wei group is mainly focused on the development of eukaryotic gene editing tools and novel nucleic acid therapeutics, with the emphasis on the high-throughput functional genomics and gene therapy. The combination of forward and reverse genetic means is employed, often in a high-throughput fashion, for the understanding of the molecular mechanisms underlying human diseases, including cancer and infection.
1. Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, Wang C, Xiao X, Dong X, Guo L, Lu S, Yang C, Tang C, Yang Y, Yu W, Wang, J, Zhou Y, Huang Q, Yisimayi A, Liu S, Huang WJ Cao Y, Wang Y, Zhou Z, Peng X, Wang J, Xie X, Wei W*. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell. doi: https://doi.org/10.1016/j.cell.2022.03.044.
2. Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, Wei W*. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology. https://doi.org/10.1038/s41587-021-01180-3.
3. Xu P, Liu Z, Liu Y, Ma H, Xu Y, Bao Y, Zhu S, Cao Z, Wu Z, Zhou Z and Wei W*. (2021) Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology. 39, 1403–1413.
4. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology. 37, 1059-1069.
5. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi YH, Gao S, Shi Y, Yan J, Zhang Y, Xie Z*, Wei WS* and Gao GF*. (2019) Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B. Cell. 177, 1-13.
6. Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, Liu Z, He Y and Wei W*. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nature Biotechnology. 36, 1203-1210.
7. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nature Biotechnology. 34, 1279-1286.
8. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509(7501): 487-91.