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Zemin Zhang, PI


T: +86-10-62768190
E: zemin@pku.edu.cn

Rm. 306, Integrated Science Research Center No.2,Peking University

Profile

  Dr. Zemin Zhang obtained his Bachelor degree in Genetics from Nankai University, PhD in Biochemistry and Molecular Biology from Penn State University, and completed his postdoctoral training in UC San Francisco. Prior to joining Peking University, Dr. Zhang spent over 16 years at Genentech/ Roche, leading the cancer genomics and bioinformatics group to discover anticancer targets and biomarkers. He has pioneered multiple research directions in computational cancer biology and cancer genomics, and is a leader in demonstrating the patterns of tumor microenvironment heterogeneity. He serves on the editorial boards for several top journals, including Cell, Cancer Cell, Cancer Discovery, and Cell Research. He is the CUSBEA Scholar and the Cheung Kong Scholar.

  Zhang Lab is devoted to using the cutting-edge genomics and bioinformatics technologies to study fundamental problems of cancer biology and tumor heterogeneity. The current main research directions include: 1) dissecting tumor microenvironment, especially the accurate composition and functional status of tumor-infiltrating immune cells; 2) dissecting the heterogeneity of the tumor microenvironment and its impact on patient treatment; 3) developing innovative bioinformatics tools and resources to analyze, integrate, and visualize genomic data.

Selected Publications

  1. D. Wang, B, Liu, and Z. Zhang*. (2023) Accelerating the understanding of cancer biology through the lens of genomics. Cell, 186:1755
  2. Z. Liu and Z. Zhang*. (2022) Mapping cell types across human tissues. Science, 376(6594):695
  3. L. Zheng, S. Qin, W. Si, …, J. Ji*, and Z. Zhang*. (2021) Pan-cancer single cell landscape of tumor-infiltrating T cells. Science, 374:abe6474
  4. S. Cheng, …, Z. Bu*, J. Ji*, and Z. Zhang*. (2021) A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell, 184:792
  5. X. Ren, …, R. Jin*, and Z. Zhang*, (2021) COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Cell, 184:1895
  6. PCAWG Transcriptome Core Group, C. Calabrese, N. R. Davidson, …, A. Brazma*, A. N. Brooks*, J. Göke*, G. Rätsch*, R. F. Schwarz*, O. Stegle*, Z. Zhang* & PCAWG Consortium. (2020) Genomic basis for RNA alterations in cancer. Nature, 578:129-136
  7. Q. Zhang, …, X. Ren*, and Z. Zhang* (2019) Landscape and dynamics of single immune cells in hepatocellular carcinoma. Cell, 179:829
  8. L. Zhang, X. Yu, L. Zheng, Y. Zhang, …, Z. Shen*, W. Ouyang*, and Z. Zhang*. (2018) Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature, 564:268
  9. C. Zheng, L. Zheng, …, W. Ouyang*, J. Peng*, and Z. Zhang*. (2017) Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell, 169, 1342