Publications -Beijing Advanced Innovation Center for Genomics

Cancer Research \| Single-cell dissection of the multiomic landscape of high-grade serous ovarian cancer
JCI \| TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma
Nucleic Acids Research \| De novo assembly of human genome at single-cell levels
GPB \| Single-cell sequencing reveals clearance of blastula chromosomal mosaicism in in vitro fertilization babies
Plos Biology \| Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development
Genome Biology \| Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis
Nat. Biotechnol. \| An accurate and robust computational method for single-cell multi-omics integration and regulatory inference
Nucleic Acids Research \|Regulatory elements can be essential for maintaining broad chromatin organization and cell viability
Cancer Cell \| Immune phenotypic linkage between colorectal cancer and liver metastasis
Cell Discovery \| Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infection
Cell Discovery ∣ Integrated single cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma
Nature Communications\| Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
Nature Biotechnology｜LEAPER 2.0: a circular RNA-based RNA editing tool with improved efficiency and fidelity
Nature Cancer \| Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer
Science \| Pan-cancer single-cell landscape of tumor-infiltrating T cells
GPB \| Systematical curation and evalutation for human expression-modulating variants
Brief. Bioinformatics \| A novel convolutional layer with adaptive kernels from Gao Lab, Peking University
Genome Biology \| A novel single-cell genome sequencing from Tang Lab, Peking University
Nat. Biotechnol. \| An efficient and precise method for high-throughput functional screens based on base editors
PLoS Biol. ∣ Dr. Lu Wen, Dr. Lei Song and Dr. Jizheng Wang Reveal Multiomics Map of Human Hearts