高歌, 研究员

http://www.gao-lab.org/
T: +86-10-62755206
E: gaog@pku.edu.cn

北京市海淀区颐和园路5号北京大学王克桢楼,100871

个人简介

2006年,高歌博士获得北京大学生物信息学博士学位,是国内自主培养的首批生物信息学博士,并于2011年获聘北京大学生命科学学院研究员。近五年来,课题组自主开发的十余个生物信息学新算法软件及数据库外部有效访问总计逾3.68亿次,其中半数以上来自海外,跻身国内自主开发最具国际影响力生物信息技术行列;高歌博士,作为主要作者在Bioinformatics、Nucleic Acids Research、Genome Research、Molecular Biology and Evolution等生物信息学与基因组学高影响力杂志上发表13篇论文中,有4篇被评列为ESI Highly Cited (Top 1%) Paper,引用数在本领域过去10年所有SCI收录论文中位列前1%;另有4篇分别入选了InCoB’16 Best Paper、Faculty of 1000 Very Good Paper,并被相应杂志标为Highly Accessed Paper。与此同时,课题组积极与国内外同行合作,作为生物信息分析合作者在Cell, Developmental Cell, Nature Communication等杂志合作发表论文12篇。

相关工作获得了国内外同行的广泛关注与认可,2011年以来,高歌博士已连续四届通过全球选举当选为亚太地区最早的生物信息学组织亚太生物信息学网络(Asia Pacific Bioinformatics Network, APBioNET)执行委员会委员暨中国联络员(Liaison), 并于2016年起任APBioNET副理事长(Vice President on Education)。2013年,高歌博士作为生物信息方向唯一人选获得国家首届万人计划青年拔尖人才计划支持,并于2014年、2015年作为专家委员暨共同发起人入选首届中国生物工程学会计算生物学与生物信息学专业委员会、首届中国遗传学会生物大数据专业委员会,并任中国人工智能学会生物信息学与人工生命专业委员会专家委员。 

作为高校教师,高歌博士在专注科研的同时潜心教学,作为主讲教师承担“生物信息学方法”、“遗传学”小班讨论课等6门校内课程教学任务,2013年秋季作为主讲教师与生命学院魏丽萍教授共同创设国际首门中英双语生物信息学慕课(MOOC),截至2017年12月共有来自全球145个国家/地区共计九万七千余名学员注册学习,授课效果获得广泛好评,并入选首届北大最受欢迎慕课课程(2014)、国家首批精品在线课程(2017),相关成果“基于慕课的生物信息学混合式教学实践”获北京大学教学成果校级一等奖、北京市市级一等奖(2013~2017)。 

高歌课题组在ICG的实验室将持续以生物信息学新技术、方法与平台开发为基础,综合运用大数据与统计学习(statistical learning)等计算方法,致力于系统解读以基因表达为中心的调控通路的功能及演化。在ICG,高歌博士将与ICG各位同仁在单细胞组学等领域开展紧密合作,以精确解读基因组功能为目标,开展高水平的生物信息学研究。


代表性论文

生物学大数据的整合与挖掘

1. Cheng S. J., Shi F. Y., Liu H., Ding Y., Jiang S., Liang N., Gao G.* 2017. Accurately annotate compound effects of genetic variants using a context-sensitive framework. Nucleic Acids Res. 45(10): e82. (Featured as “Highly Accessed”)

2. Hou M., Tian F., Jiang S., Kong L., Yang D., Gao G.* 2016a. LocExpress: a web server for efficiently estimating expression of novel transcripts. BMC Genomics 17(13): 175-179. (Featured as Best Paper at InCoB’16)

3. Hou M., Tang X., Tian F., Shi F., Liu F., Gao G.* 2016b. AnnoLnc: a web server for systematically annotating novel human lncRNAs. BMC Genomics 17(1): 931.

4. Hu B., Jin J., Guo A. Y., Zhang H., Luo J., Gao G.* 2015. GSDS 2.0: an upgraded gene feature visualization server. Bioinformatics 31(8): 1296-1297. (Featured as ESI Highly Cited (Top 1%) Paper)

5. Xiao A., Cheng Z., Kong L., Zhu Z., Lin S., Gao G.*, Zhang B.* 2014. CasOT: a genome-wide Cas9/gRNA off-target searching tool. Bioinformatics 30(8): 1180-1182. (Featured as ESI Highly Cited (Top 1%) Paper)

6. Kong L., Wang J., Zhao S., Gu X., Luo J.*, Gao G.* 2012. ABrowse - a customizable next-generation genome browser framework. BMC Bioinformatics 13: 2. (Featured as “Highly Accessed”)

7. Wang J., Kong L., Zhao S., Zhang H., Tang L., Li Z., Gu X., Luo J.*, Gao G.* 2011. Rice-Map: a new-generation rice genome browser. BMC Genomics 12: 165. (Featured as “Highly Accessed”)

调控网络的功能与演化 

8. Jin J., Tian F., Yang D. C., Meng Y. Q., Kong L., Luo J., Gao G.* 2017. PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants. Nucleic Acids Res 45(D1): D1040-D1045. (Featured as ESI Highly Cited (Top 1%) Paper)

9. Jin J., He K., Tang X., Li Z., Lv L., Zhao Y., Luo J., Gao G.* 2015. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol Biol Evol 32(7): 1767-1773.

10. Zhao Y., Tang L., Li Z., Jin J., Luo J., Gao G.* 2015. Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics. BMC Evol Biol 15: 66. (Featured as “Very Good (being of special significance in its field)” by Faculty of 1000)

11. Gao G., Vibranovski M. D., Zhang L., Li Z., Liu M., Zhang Y. E., Li X., Zhang W., Fan Q., VanKuren N. W., Long M., Wei L. 2014. A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res 24(4): 629-638.

12. Jin J., Zhang H., Kong L., Gao G.*, Luo J.* 2014. PlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors. Nucleic Acids Res 42(1): D1182-1187. (Featured as ESI Highly Cited (Top 1%) Paper)

13. Tang X., Hou M., Ding Y., Li Z., Ren L., Gao G.* 2013. Systematically profiling and annotating long intergenic non-coding RNAs in human embryonic stem cell. BMC Genomics 14(Suppl 5): S3. (Featured as “Highly Accessed”)

14. Chen Z. X., Zhang Y. E., Vibranovski M., Luo J., Gao G.*, Long M.* 2011. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol 28(10): 2823-2832. 

慕课教学

15. Ding Y., Wang M., He Y., Ye A. Y., Yang X., Liu F., Meng Y., Gao G.*, Wei L.* 2014. `Bioinformatics: Introduction and Methods,` a Bilingual Massive Open Online Course (MOOC) as a New Example for Global Bioinformatics Education. PLoS Computational Biology 10(12): e1003955.

部分合作论文

1. Zhou Y., Wang P., Tian F., Gao G., Huang L., Wei W., Xie X. S. 2017. Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. Cell Res 27(2): 298-301.

2. Feng S., Zhao Y., Xu Y., Ning S., Huo W., Hou M., Gao G., Ji J., Guo R.*, Xu D.* 2016. Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem 291(42): 21956-21962.

3. Xing M., Yang M., Huo W., Feng F., Wei L., Jiang W., Ning S., Yan Z., Li W., Wang Q., Hou M., Dong C., Guo R., Gao G., Ji J., Zha S., Lan L., Liang H., Xu D. 2015. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun 6: 6233.

4. Shu J., Wu C., Wu Y., Li Z., Shao S., Zhao W., Tang X., Yang H., Shen L., Zuo X., Yang W., Shi Y., Chi X., Zhang H., Gao G., Shu Y., Yuan K., He W., Tang C.*., Zhao Y., Deng HK.*. 2013. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 153(5): 963-975.

5. Yue R., Li H., Liu H., Li Y., Wei B., Gao G., Jin Y., Liu T., Wei L., Du J., Pei G.* 2012. Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition. Dev Cell 22(5): 1092-1100.